Original paper
Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone
Abstract
Resistant hypertension is a major health concern with unknown cause. Spironolactone is an effective antihypertensive drug, especially for patients with resistant hypertension, and is considered by the World Health Organization as an essential medication. Although spironolactone can act at the mineralocorticoid receptor (MR; NR3C2), there is increasing evidence of MR-independent effects of spironolactone.Here, we detail the unexpected discovery...
Paper Details
Title
Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone
Published Date
Feb 16, 2018
Journal
Volume
122
Issue
4
Pages
606 - 615
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Notes
History