Unmasking Plasma Membrane Blebbing

The eukaryotic cell plasma membrane is tightly connected to the underlying cytoskeletal network. When this close association is disrupted, the overlying plasma membrane detaches from the cortical actin and bulges out due to intracellular hydrostatic pressure-driven cytosolic fluid and lipids flow resulting in the formation of spherical, blister-like protrusions called blebs. Membrane blebs have been observed during normal biological and...