Original paper

Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates

Volume: 28, Issue: 3, Pages: 503 - 508
Published: Feb 1, 2018
Abstract
Asialoglycoprotein receptor (ASGP-R) belongs to a wide family of C-type lectins and it is currently regarded as an attractive protein in the field of targeted drug delivery (TDD). It is abundantly expressed in hepatocytes and can be found predominantly on the sinusoidal surface especially of HepG2 cells. Therefore, ASGP-R can be used for the TDD of anticancer therapeutics against HCC and molecular diagnostic tools. To date, a variety of mono-...
Paper Details
Title
Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates
Published Date
Feb 1, 2018
Volume
28
Issue
3
Pages
503 - 508
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