Potent aromatase inhibitors and molecular mechanism of inhibitory action
Abstract
Estrogen is a significant factor in the maintenance and progression of hormone-dependent breast cancer. As well known, aromatase mediates the production of estrogen. Thus, inhibition of aromatase with chemical molecules has been considered to be an effective treatment for estrogen receptor-positive (ER+) breast cancer. In this work, we designed and synthesized a series of novel non-steroidal molecules containing 2-phenylindole scaffold and...
Paper Details
Title
Potent aromatase inhibitors and molecular mechanism of inhibitory action
Published Date
Jan 1, 2018
Volume
143
Pages
426 - 437
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