Effects of Tissue-Specific Functional Magnetic Resonance Imaging Signal Regression on Resting-State Functional Connectivity

Neuroimaging studies typically consider white matter as unchanging in different neural and metabolic states. However, a recent study demonstrated that white matter signal regression (WMSR) produced a similar loss of neurometabolic information to global (whole-brain) signal regression (GSR) in resting-state functional magnetic resonance imaging (R-fMRI) data. This was unexpected as the loss of information would normally be attributed to neural...