Maternal and fetal blood lipid concentrations during pregnancy differ by maternal body mass index: findings from the ROLO study

Published on Oct 16, 2017in BMC Pregnancy and Childbirth3.007
· DOI :10.1186/S12884-017-1543-X
Aisling A. Geraghty10
Estimated H-index: 10
(UCD: University College Dublin),
Goiuri Alberdi9
Estimated H-index: 9
(UCD: University College Dublin)
+ 4 AuthorsFionnuala M. McAuliffe58
Estimated H-index: 58
(UCD: University College Dublin)
Sources
Abstract
Background Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, blood lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension and high birth weight. As blood lipids are not routinely measured during pregnancy, there is limited information on what is considered normal during pregnancy and in fetal blood.
Figures & Tables
Download
📖 Papers frequently viewed together
References35
Newest
INTRODUCTION: The influence of maternal body mass index (BMI) on respiratory quotient during pregnancy is not clear. We aim to evaluate longitudinal changes in energy expenditure, respiratory quotient, and substrate oxidation rates in normal and overweight women with uncomplicated pregnancies. We hypothesized that the threshold period in switching from a predominantly carbohydrate to a predominantly lipid metabolism may be different in normal and overweight women. MATERIAL AND METHODS: Forty hea...
Source
#1Aisling A. Geraghty (UCD: University College Dublin)H-Index: 10
#2Goiuri Alberdi (UCD: University College Dublin)H-Index: 9
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
view all 7 authors...
Background The in-utero environment affects fetal development; it is vital to understand how maternal diet during pregnancy influences childhood body composition. While research indicates that triglycerides in hyperglycaemic women may increase birth weight, little is known about this relationship in euglycemic women. This study examines the relationship between maternal blood lipid status and infant adiposity up to 2 years of age. Methods Data from 331 mother-child pairs from the ROLO longitudin...
Source
#1Anna Gergely (MTA: Hungarian Academy of Sciences)H-Index: 8
#2Anna B. Compton (NMBU: Norwegian University of Life Sciences)H-Index: 1
Last. Ádám Miklósi (ELTE: Eötvös Loránd University)H-Index: 79
view all 4 authors...
Mechanical “unidentified moving objects” (UMO’s) are useful for controlled investigations into features of social interaction that generate cooperativeness and positive social affiliation in domestic dogs (Canis familiaris). We hypothesized that, if a UMO interacted socially with a dog, the UMO would become associated with certain social cues and would subsequently affect dog behaviour. We assigned dogs to a Human, Social UMO or Non-Social UMO partner. In the Human and Social UMO conditions, the...
Source
#1Wan N. Wan Sulaiman (Glas.: University of Glasgow)H-Index: 1
#2Muriel J. Caslake (Glas.: University of Glasgow)H-Index: 69
Last. Dilys J. Freeman (Glas.: University of Glasgow)H-Index: 30
view all 7 authors...
The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit of its functionality ra...
Source
#1Chen Wang (PKU: Peking University)H-Index: 14
#2Weiwei Zhu (PKU: Peking University)H-Index: 14
Last. Huixia Yang (PKU: Peking University)H-Index: 37
view all 7 authors...
This study aimed at evaluating the predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus (GDM) in patients stratified by prepregnancy body mass index (p-BMI) and to determine the optimal cut-off values of each indicator for different p-BMI ranges. A retrospective system cluster sampling survey was conducted in Beijing during 2013 and a total of 5,265 singleton pregnancies without prepregnancy diabetes were included. The information ...
Source
#1Andrea Leiva (UC: Pontifical Catholic University of Chile)H-Index: 27
#2Rocío Salsoso (UC: Pontifical Catholic University of Chile)H-Index: 19
Last. Luis Sobrevia (University of Seville)H-Index: 50
view all 6 authors...
Introduction: Maternal hypercholesterolemia and hypertriglyceridemia during pregnancy is correlated with fetoplacental endothelial dysfunction and atherosclerotic lesions in fetal arteries. Few studies have reported the distribution of the concentrations of maternal total cholesterol (TCh), lipoprotein cholesterol and triglycerides during pregnancy. Therefore, we determined maternal lipid concentration during pregnancy and established the percentiles over which fetoplacental endothelial dysfunct...
Source
#1Kelli K. Ryckman (UI: University of Iowa)H-Index: 31
#2Cassandra N. Spracklen (UI: University of Iowa)H-Index: 19
Last. Audrey F. Saftlas (UI: University of Iowa)H-Index: 33
view all 5 authors...
Background Lipid levels during pregnancy in women with gestational diabetes mellitus (GDM) have been extensively studied; however, it remains unclear whether dyslipidaemia is a potential marker of preexisting insulin resistance. Objective To evaluate the relationship between lipid measures throughout pregnancy and GDM. Search strategy We searched PubMed-MedLine and SCOPUS (inception until January 2014) and reference lists of relevant studies. Selection criteria Publications describing original d...
Source
#1Helen L. Barrett (Royal Brisbane and Women's Hospital)H-Index: 23
#2Marloes Dekker Nitert (Royal Brisbane and Women's Hospital)H-Index: 34
Last. Leonie K. Callaway (Royal Brisbane and Women's Hospital)H-Index: 37
view all 4 authors...
Pre-eclampsia continues to be a challenge – to understand the underlying pathogenesis and to prevent or treat in the clinical setting. One area of potential therapies opening up is treatment of maternal lipids and clinical trials are underway using statins in early pre-eclampsia. At present, most potential therapies to treat lipids cannot be recommended for general use in pregnancy and if we were to target maternal lipids to reduce rates of pre-eclampsia, very large numbers of women may need to ...
Source
#1Mary K. Horan (UCD: University College Dublin)H-Index: 9
#2Ciara A. McGowan (UCD: University College Dublin)H-Index: 15
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
view all 5 authors...
Background: The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity. Methods: This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence o...
Source
#1Mary K. Horan (UCD: University College Dublin)H-Index: 9
#2Ciara A. McGowan (UCD: University College Dublin)H-Index: 15
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
view all 5 authors...
Pregnancy increases the risk of being overweight at a later time period, particularly when there is excessive gestational weight gain. There remains a paucity of data into the effect of low glycaemic index (GI) pregnancy interventions postpartum. Aim: To examine the impact of a low glycaemic index diet during pregnancy on maternal diet 3 months postpartum. Methodology: This analysis examined the diet, weight and lifestyle of 460 participants of the ROLO study 3 months postpartum. Questionnaires ...
Source
Cited By41
Newest
#1Adeyinka Emmanuel Adegbosin (Griffith University)H-Index: 4
#2Jan Warnken (Griffith University)H-Index: 24
Last. Jing Sun (Griffith University)H-Index: 37
view all 3 authors...
Objective: To investigate geographical inequalities and changes in the quality of emergency obstetric care services available in Haiti over time. Methods: We utilised data from the Service Provision Assessment (SPA) survey of all health facilities in Haiti in 2013 and 2017.We developed a quality index for Basic and Comprehensive Emergency Obstetric Care (BEmOC and CEmOC) based on the items in the signal functions of emergency obstetric care framework, using a structure, process and outcome frame...
Source
#1Aduragbemi Banke-Thomas (LSE: London School of Economics and Political Science)H-Index: 11
#2Kerry L. M. Wong (Lond: University of London)H-Index: 16
Last. Akin AbayomiH-Index: 5
view all 11 authors...
Previous efforts to estimate travel time to comprehensive emergency obstetric care (CEmOC) in low- and middle-income countries (LMICs) have either been based on spatial models or self-reported travel time, both with known inaccuracies. The study objectives were to estimate more realistic travel times for pregnant women in emergency situations using Google Maps, determine system-level factors that influence travel time, and use these estimates to assess CEmOC geographical accessibility and covera...
Source
#1Matthew Bucher (OHSU: Oregon Health & Science University)H-Index: 3
#2Kim Ramil C. Montaniel (OHSU: Oregon Health & Science University)H-Index: 8
Last. Alina Maloyan (OHSU: Oregon Health & Science University)H-Index: 26
view all 6 authors...
Obesity is a chronic condition associated with dyslipidemia and insulin resistance. Here, we show that the offspring of obese mothers are dyslipidemic and insulin resistant from the outset.Maternal and cord blood and placental tissues were collected following C-section at term. Patients were grouped as being normal weight (NW, BMI = 18-24.9) or obese (OB, BMI ≥ 30), and separated by fetal sex. We measured plasma lipids, insulin, and glucose in maternal and cord blood. Insulin resistance was quan...
Source
#1Assumpta Yamuragiye (NUR: National University of Rwanda)
#2Lloy Wylie (UWO: University of Western Ontario)H-Index: 5
Last. Lorie Donelle (UWO: University of Western Ontario)H-Index: 14
view all 4 authors...
Source
#1Ranjita Ghosh (International Institute for Population Sciences)
#2Arupendra Mozumdar (Population Council)H-Index: 14
Last. Rajib Acharya (Population Council)H-Index: 21
view all 4 authors...
Since the inception of the National Programme for Family Planning, messages on family planning (FP) have been promoted across India using different mass media platforms. Mass media plays an important role in disseminating important information among the masses, such as how reversible modern methods give women more reproductive choices than opting for permanent methods that limit their child-bearing capacity. Mass media can provide a continuous flow of information and motivation to deter women fr...
Source
#1Akosua Agyenim-Boateng (University of Salford)
#2Helen Cameron (University of Salford)
Last. Adwoa Bemah Boamah Mensah (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 3
view all 3 authors...
Abstract null null Background null The interest of the global community in improving women’s experiences with childbirth has led to interventions such as facility-based childbirth and the use of skilled birth attendants. However, reports of low facility and skilled birth attendants use continue to exist in literature because of disrespectful and abusive care directed at women during childbirth. null The present systematic review examined the question “What are the understanding and justification...
Source
view all 4 authors...
Introduction and Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the common causes of liver cirrhosis among general population.Studieshave identified NAFLD and evaluated lipid profile in pregnant women. Some have explored association that existed between lipid levels and adverse pregnancy outcome in western countries. Our aim was to find the prevalence of non-alcoholic fatty liver disease (NAFLD) in pregnant women among rural population in their III trimester and to assess dyslipidemia ...
Source
#1Qiping Fan (Duke University)H-Index: 4
#2Maria Roque (Texas A&M Health Science Center)
Last. Ping Ma (Texas A&M Health Science Center)H-Index: 16
view all 10 authors...
BACKGROUND Antenatal care (ANC), delivery by skilled birth attendants, and postnatal care (PNC) are critical components of maternal health services for reducing maternal mortality. The study aimed to compare the utilization of maternal health services in the two most recent rounds of Ethiopia Demographic and Health Surveys (EDHS) and identify the factors influencing the utilization of these services using the 2016 EDHS. METHODS Two rounds of EDHS data in 2011 and 2016 were used to estimate the p...
Source
#1Madeleine F Cohen (Emory University)H-Index: 1
#2Elizabeth J. Corwin (Emory University)H-Index: 30
Last. Patricia A. Brennan (Emory University)H-Index: 65
view all 4 authors...
Objective: Previous longitudinal studies have demonstrated prospective relationships between maternal sleep quality and subsequent psychological distress in the postpartum period. Despite evidence for prospective relationships between mood and subsequent sleep quality in adult populations, this direction has not been examined in postpartum women. We aimed to test prospective relationships between sleep quality and subsequent psychological distress, as well as the plausible reverse possibility, i...
Source
#1Chun Tong (PKU: Peking University)H-Index: 1
#2Gong Lijun (PKU: Peking University)H-Index: 1
Last. Pengbo Yuan (PKU: Peking University)H-Index: 3
view all 6 authors...
BACKGROUND Uterine rupture is a rare, life-threatening event in obstetrics that may be fatal for the mother and fetus. Therefore, obstetricians need to pay attention to and should consider the antenatal diagnosis of uterine rupture in women having its risk factors. Successful conservative management for asymptomatic uterine rupture due to previous laparoscopic surgery for interstitial pregnancy has already been reported but remains understudied. CASE PRESENTATION A 39-year-old woman was diagnose...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.