Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4
Abstract
The insulin-regulated glucose transporter, GluT4, is a key molecule in peripheral insulin signaling. Although GluT4 is abundantly expressed in neurons of specific brain regions such as the hippocampus, the functional role of neuronal GluT4 is unclear. Here, we used pharmacological inhibition of GluT4-mediated glucose uptake to determine whether GluT4 mediates insulin-mediated glucose uptake in the hippocampus. Consistent with previous reports,...
Paper Details
Title
Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4
Published Date
Feb 1, 2018
Journal
Volume
338
Pages
32 - 39
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