Abstract: Oncologic Safety of Fat Grafting in Breast Reconstruction: A New Clinically Relevant Animal Model of Residual Breast Cancer

INTRODUCTION: Autologus fat grafting is becoming widely used for breast reconstruction. However, the bioactive adipose stromal cells have been shown in many in vitro and animal studies to promote cancer cell growth. We report a new animal model that accurately simulates the clinical scenario of reconstructive fat grafting. METHODS: 40 female NOD-SCID gamma mice were injected with 1K MCF7 breast cancer cells in 4 sites of mammary fat pads. After...