Nursing

Voltage

Engineering

Pure mathematics

Point of care

Biology

Materials science

Ebolavirus

Graphene

Field (mathematics)

Virology

Computer science

Ebola virus

Outbreak

Computational biology

Biosensor

Immunology

Transistor

Nanotechnology

Mathematics

Antigen

Field-effect transistor

Medicine

Virus

Electrical engineering

Scientific Reports

The Ebola virus transmits a highly contagious, frequently fatal human disease for which there is no specific antiviral treatment. Therefore, rapid, accurate, and early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, particularly in developing countries where resources are few and EVD is endemic. We have developed a reduced graphene oxide-based field-effect transistor method for real-time detection of the Ebola virus antigen. This method uses the attractive semiconductor characteristics of graphene-based material, and instantaneously yields highly sensitive and specific detection of Ebola glycoprotein. The feasibility of this method for clinical application in point-of-care technology is evaluated using Ebola glycoprotein suspended in diluted PBS buffer, human serum, and plasma. These results demonstrate the successful fabrication of a promising field-effect transistor biosensor for EVD diagnosis.

Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen