In vivo evaluation of voriconazole eye drops efficacy in a rat Acanthamoeba polyphaga keratitis model

Purpose Acanthamoeba keratitis is a sight-threatening infectious disease. Its effective and safe medical therapy remains highly debated. The aim of this study is to test in vitro and in vivo voriconazole as a potential antiamoebic treatment for Acanthamoeba keratitis. Methods In vitro sensitivity of Acanthamoeba polyphaga to voriconazole was assessed using a commercially available viability assay. In vivo, Sprague-Dawley male rats were injected...