Review paper
Inotuzumab Ozogamicin: First Global Approval
Abstract
Intravenous inotuzumab ozogamicin (Besponsa®; Pfizer) is an anti-CD22 monoclonal antibody-calicheamicin conjugate that binds to CD22-expressing tumour cells. Upon binding, the complex is internalised and the cytotoxic calicheamicin derivative is released inside the cell, inducing double-strand DNA breakage and subsequent cell death. In June 2017, the EMA granted inotuzumab ozogamicin approval as monotherapy for the treatment of adults with...
Paper Details
Title
Inotuzumab Ozogamicin: First Global Approval
Published Date
Aug 17, 2017
Journal
Volume
77
Issue
14
Pages
1603 - 1610
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Notes
History