Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy

The objective of this study was to determine whether disagreements among multiple data sources affect systematic reviews of randomized clinical trials (RCTs).Eligible RCTs examined gabapentin for neuropathic pain and quetiapine for bipolar depression, reported in public (e.g., journal articles) and nonpublic sources (clinical study reports [CSRs] and individual participant data [IPD]).We found 21 gabapentin RCTs (74 reports, 6 IPD) and 7...