The gut microbiome in IBD is characterized by impaired metabolic cooperativity and can be restored upon anti-TNFα therapy

Blocking TNFα is an important treatment option for inflammatory bowel disease (IBD). The etiology of the disorder comprises a permanent activation of immune cascades and imbalanced cytokine networks. Evidence has been put forward that alteration of the human gut microbiome may play a critical role in the pathogenesis of IBD. However, the impact of targeted cytokine blockade on dysbiosis of intestinal microbial communities is poorly understood....