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Original paper

Runx3 plays a critical role in restriction-point and defense against cellular transformation

Volume: 36, Issue: 50, Pages: 6884 - 6894
Published: Aug 28, 2017
Abstract
The restriction (R)-point decision is fundamental to normal differentiation and the G1-S transition, and the decision-making machinery is perturbed in nearly all cancer cells. The mechanisms underlying the cellular context-dependent R-point decision remain poorly understood. We found that the R-point was dysregulated in Runx3-/-mouse embryonic fibroblasts (MEFs), which formed tumors in nude mice. Ectopic expression of Runx3 restored the R-point...
Paper Details
Title
Runx3 plays a critical role in restriction-point and defense against cellular transformation
Published Date
Aug 28, 2017
Journal
Volume
36
Issue
50
Pages
6884 - 6894
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