Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Abstract
Cancer cells are hallmarked by high proliferation and imbalanced redox consumption and signaling. Various oncogenic pathways such as proliferation and evading cell death converge on redox-dependent signaling processes. Nrf2 is a key regulator in these redox-dependent events and operates in cytoprotection, drug metabolism and malignant progression in cancer cells. Here, we show that patients with primary malignant brain tumors (glioblastomas, WHO...
Paper Details
Title
Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
Published Date
Aug 14, 2017
Journal
Volume
6
Issue
8
Pages
e371 - e371
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