Progress in targeting the BCL-2 family of proteins
Abstract
The network of protein–protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches...
Paper Details
Title
Progress in targeting the BCL-2 family of proteins
Published Date
Aug 1, 2017
Volume
39
Pages
133 - 142
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