Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter

Volume: 45, Issue: 17, Pages: 10132 - 10142
Published: Jul 29, 2017
Abstract
EGFR is an oncogene which codifies for a tyrosine kinase receptor that represents an important target for anticancer therapy. Indeed, several human cancers showed an upregulation of the activity of this protein. The promoter of this gene contains some G-rich domains, thus representing a yet unexplored point of intervention to potentially silence this gene. Here, we explore the conformational equilibria of a 30-nt long sequence located at...
Paper Details
Title
Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter
Published Date
Jul 29, 2017
Volume
45
Issue
17
Pages
10132 - 10142
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