Review paper
The emerging role and targetability of the TCA cycle in cancer metabolism
Abstract
The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence demonstrates that certain cancer cells, especially those with deregulated oncogene and tumor suppressor expression, rely heavily on the TCA cycle for energy...
Paper Details
Title
The emerging role and targetability of the TCA cycle in cancer metabolism
Published Date
Jul 26, 2017
Journal
Volume
9
Issue
2
Pages
216 - 237
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