Original paper
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals
Abstract
Infections with the Zika virus (ZIKV) are responsible for congenital abnormalities and neurological disorders. We here demonstrate that ZIKV productively infects three types of human iPSC (induced pluripotent stem cells)-derived cells from the neural lineage, i.e. cortical and motor neurons as well as astrocytes. ZIKV infection results in all three cell types in the production of infectious virus particles and induces cytopathic effects (CPE)....
Paper Details
Title
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals
Published Date
Jul 20, 2017
Journal
Volume
145
Pages
82 - 86