Preparation and optimization of rivastigmine-loaded tocopherol succinate-based solid lipid nanoparticles
Abstract
Rivastigmine hydrogen tartrate (RHT) is a pseudo-irreversible inhibitor of cholinesterase and is used for the treatment of Alzheimer's. However, RHT delivery to the brain is limited by the blood-brain barrier (BBB). The purpose of this study was to improve the brain-targeting delivery of RHT by producing and optimizing rivastigmine hydrogen tartrate-loaded tocopherol succinate-based solid lipid nanoparticles (RHT-SLNs). RHT-SLNs were prepared...
Paper Details
Title
Preparation and optimization of rivastigmine-loaded tocopherol succinate-based solid lipid nanoparticles
Published Date
Jul 19, 2017
Journal
Volume
28
Issue
3
Pages
226 - 235
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Notes
History