Original paper

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

Volume: 57, Pages: 29 - 34
Published: Sep 1, 2017
Abstract
The ATM kinase plays critical roles in the response to DNA double-strand breaks, and can also be activated by prolonged DNA replication blocks. It has recently been proposed that replication stress-dependent ATM activation is mediated by ASCIZ (also known as ATMIN, ZNF822), an essential developmental transcription factor. In contrast, we show here that ATM activation, and phosphorylation of its substrates KAP1, p53 and H2AX in response to the...
Paper Details
Title
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress
Published Date
Sep 1, 2017
Journal
Volume
57
Pages
29 - 34
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