Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

In this Review, the authors describe the factors that influence the development of hepatic steatosis and discuss the evidence base that links steatosis to insulin resistance. They explore how steatosis alters the secretion of hepatokines from the liver, and how these secretome alterations regulate glucose metabolism and insulin action in non-hepatic tissues. Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD),...