Statistics

Cervical intraepithelial neoplasia

Cervical cancer

Cancer

Visual inspection

Cervix

Cochrane Library

Mathematics

Meta-analysis

Internal medicine

Colposcopy

Medicine

Gynecology

Obstetrics

Confidence interval

BJOG An International Journal of Obstetrics & Gynaecology

Background Visual inspection of the cervix with acetic acid ( VIA ) or with Lugol's iodine ( VILI ) have been evaluated for cervical cancer screening in developing countries. Objectives To assess the diagnostic accuracy and clinical utility of visual methods to detect cervical intraepithelial neoplasia grade 2+ ( CIN 2+) using: (1) VIA alone; (2) VILI alone; (3) co‐testing; and (4) VILI as a triage test of a positive VIA result. Search strategy PubMed, EMBASE , and the Cochrane Library were searched up to May 2016. Selection criteria All reports on the accuracy of VIA and VILI , or combinations of VIA / VILI , to detect CIN 2+ were identified. Histology and colposcopy when no biopsy was taken were used as the reference standard. Data collection and analysis Selected studies were scored on methodological quality, and sensitivity and specificity were computed. Clinical utility was assessed from the positive predictive value ( PPV ) and the complement of the negative predictive value ( cNPV ). Main results We in...

Accuracy of combinations of visual inspection using acetic acid or lugol iodine to detect cervical precancer: a meta‐analysis