Original paper
Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
Abstract
Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium...
Paper Details
Title
Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
Published Date
May 26, 2017
Volume
60
Issue
12
Pages
5015 - 5028