Chemistry

Blood–brain barrier

Transferrin receptor

Receptor

Central nervous system

Nanocarriers

Drug delivery to the brain

Neuroscience

Organic chemistry

Biology

Transferrin

Lactoferrin

Endocytosis

Pharmacology

Drug delivery

Medicine

Transcytosis

Targeted drug delivery

Liposome

Drug

Biochemistry

Journal of Controlled Release

In this modern era, with the help of various advanced technologies, medical science has overcome most of the health-related issues successfully. Though, some diseases still remain unresolved due to various physiological barriers. One such condition is Alzheimer; a neurodegenerative disorder characterized by progressive memory impairment, behavioral abnormalities, mood swing and disturbed routine activities of the person suffering from. It is well known to all that the brain is entirely covered by a protective layer commonly known as blood brain barrier (BBB) which is responsible to maintain the homeostasis of brain by restricting the entry of toxic substances, drug molecules, various proteins and peptides, small hydrophilic molecules, large lipophilic substances and so many other peripheral components to protect the brain from any harmful stimuli. This functionally essential structure creates a major hurdle for delivery of any drug into the brain. Still, there are some provisions on BBB which facilitate the e...

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease