Original paper
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
Abstract
MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages. In healthy individuals we identified MR1-restricted T cells (named MR1T cells) displaying diverse TCRs and reacting to MR1-expressing cells in the absence of microbial ligands. Analysis of MR1T cell clones revealed specificity for...
Paper Details
Title
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
Published Date
May 18, 2017
Journal
Volume
6