Metal-Organic Frameworks at the Biointerface: Synthetic Strategies and Applications

Published on May 10, 2017in Accounts of Chemical Research22.384
· DOI :10.1021/ACS.ACCOUNTS.7B00090
Christian J. Doonan53
Estimated H-index: 53
(University of Adelaide),
Raffaele Ricco26
Estimated H-index: 26
(Graz University of Technology)
+ 2 AuthorsPaolo Falcaro54
Estimated H-index: 54
(University of Adelaide)
ConspectusMany living organisms are capable of producing inorganic materials of precisely controlled structure and morphology. This ubiquitous process is termed biomineralization and is observed in nature from the macroscale (e.g., formation of exoskeletons) down to the nanoscale (e.g., mineral storage and transportation in proteins). Extensive research efforts have pursued replicating this chemistry with the overarching aims of synthesizing new materials of unprecedented physical properties and understanding the complex mechanisms that occur at the biological–inorganic interface.Recently, we demonstrated that a class of porous materials termed metal–organic frameworks (MOFs) can spontaneously form on protein-based hydrogels via a process analogous to natural matrix-mediated biomineralization. Subsequently, this strategy was extended to functional biomacromolecules, including proteins and DNA, which have been shown to seed and accelerate crystallization of MOFs. Alternative strategies exploit co-precipita...
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