Dynamics of DNA Knots during Chain Relaxation

Volume: 50, Issue: 10, Pages: 4074 - 4082
Published: May 8, 2017
We perform single-molecule experiments and simulations to study the swelling of complex knots in linearly extended DNA molecules. We induce self-entanglement of DNA molecules in a microfluidic T-junction using an electrohydrodynamic instability and then stretch the molecules using divergent electric fields. After the chain is fully extended, the knot appears as a region of excess fluorescent brightness, and we shut off the field and observe the...
Paper Details
Dynamics of DNA Knots during Chain Relaxation
Published Date
May 8, 2017
4074 - 4082
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