Original paper
Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes
Abstract
Hsp70 participates in a broad spectrum of protein folding processes extending from nascent chain folding to protein disaggregation. This versatility in function is achieved through a diverse family of J-protein cochaperones that select substrates for Hsp70. Substrate selection is further tuned by transient complexation between different classes of J-proteins, which expands the range of protein aggregates targeted by metazoan Hsp70 for...
Paper Details
Title
Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes
Published Date
May 15, 2017
Journal
Volume
6
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Notes
History