Structural and Mechanistic Insights into Protein Translocation

Volume: 33, Issue: 1, Pages: 369 - 390
Published: Oct 6, 2017
Abstract
Many proteins are translocated across the endoplasmic reticulum (ER) membrane in eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal sequences or transmembrane (TM) segments to trigger their translocation through the protein-conducting Sec61/SecY channel. Substrates are first directed to the channel by cytosolic targeting factors, which use hydrophobic pockets to bind diverse signal and TM sequences....
Paper Details
Title
Structural and Mechanistic Insights into Protein Translocation
Published Date
Oct 6, 2017
Volume
33
Issue
1
Pages
369 - 390
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