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Original paper

Total Syntheses of Naucleamides A–C and E, Geissoschizine, Geissoschizol, (E)-Isositsirikine, and 16-epi-(E)-Isositsirikine

Volume: 19, Issue: 10, Pages: 2642 - 2645
Published: May 3, 2017
Abstract
A divergent approach for the enantioselective total synthesis of eight monoterpenoid indole alkaloids was developed. The approach allows the first total syntheses of naucleamides A–C and E in only 6–8 steps and also enables the efficient synthesis of geissoschizine, geissoschizol, (E)-isositsirikine, and 16-epi-(E)-isositsirikine in 10–11 steps from commercially available crotonic aldehyde. The synthesis features a one-pot organocatalyzed...
Paper Details
Title
Total Syntheses of Naucleamides A–C and E, Geissoschizine, Geissoschizol, (E)-Isositsirikine, and 16-epi-(E)-Isositsirikine
Published Date
May 3, 2017
Volume
19
Issue
10
Pages
2642 - 2645
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