Effect of Doxycycline on Epithelial-Mesenchymal Transitionviathe p38/Smad Pathway in Respiratory Epithelial Cells

Purpose Doxycycline has antibacterial and anti-inflammatory effects, and it also suppresses collagen biosynthesis. This study aimed to confirm the effects and mechanism of doxycycline on transforming growth factor (TGF) beta 1 induced epithelial-mesenchymal transition and cell migration in A549 and primary nasal epithelial cells. Methods A 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay and phalloidin-fluorescein isothiocyanate...