Inhibitors of cytochrome P450 (CYP) 1B1

Volume: 135, Pages: 296 - 306
Published: Jul 1, 2017
Abstract
Human cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of various drugs. This enzyme catalyzes the hydroxylation of aryl compounds, thus generating more polar metabolites that can be easily excreted. CYP1B1 is also known for its ability to activate procarcinogens into carcinogens. For example, it can hydroxylate 17β-estradiol (E2) into 4-hydroxy-E2, which can promote tumorigenesis as a potent estrogen, or after being transformed into...
Paper Details
Title
Inhibitors of cytochrome P450 (CYP) 1B1
Published Date
Jul 1, 2017
Volume
135
Pages
296 - 306
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