Original paper
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
Abstract
Hepatocellular carcinoma ( HCC ) is among the most common and deadliest cancers worldwide. A major contributor to HCC progression is the cross talk between tumor cells and the surrounding stroma including activated hepatic stellate cells ( HSC ). Activation of HSC during liver damage leads to upregulation of the orphan receptor endosialin ( CD 248), which contributes to regulating the balance of liver regeneration and fibrosis. Based on the...
Paper Details
Title
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
Published Date
Apr 3, 2017
Journal
Volume
9
Issue
6
Pages
741 - 749