Sertoli and Granulosa Cell-Specific Vascular Endothelial Growth Factor (VEGF) Loss Using pDMRT-1 Cre Alters Gonadal Morphogenesis and Function.

Inhibition of VEGF disrupts both testis-specific vascular development and cord formation. In the female, VEGF isoforms regulate follicle development and may affect the initial primordial follicle pool. Therefore, the objective of the current study was to evaluate effects of Sertoli and Granulosa cell-specific production of VEGF isoforms on vascular development and gonadal morphogenesis. The pDmrt1 gene is expressed in the indifferent gonad at...