Original paper
Microglial repopulation resolves inflammation and promotes brain recovery after injury
Abstract
Microglia mediate chronic neuroinflammation following central nervous system (CNS) disease or injury, and in doing so, damage the local brain environment by impairing recovery and contributing to disease processes. Microglia are critically dependent on signaling through the colony-stimulating factor 1 receptor (CSF1R) and can be eliminated via administration of CSF1R inhibitors. Resolving chronic neuroinflammation represents a universal goal for...
Paper Details
Title
Microglial repopulation resolves inflammation and promotes brain recovery after injury
Published Date
Mar 2, 2017
Journal
Volume
65
Issue
6
Pages
931 - 944