Specific inhalation challenge: the relationship between response, clinical variables and lung function

The specific inhalation challenge (SIC) is considered the gold standard for the diagnosis of occupational asthma (OA). However, its use is not standardised, and the intensity of exposure is regulated empirically. The aim of this study was to identify clinical variables and/or pulmonary function variables able to predict the scale of patients' response to SIC.All patients who underwent SIC at our centre between 2005 and 2013 were studied....