Vascular Endothelial Growth Factor A (VEGFA) Isoform Loss Reduces Ovarian Size, Estrogen Concentrations, mRNA Abundance of Genes Critical to Follicular Development and Oocyte Growth Resulting in Subfertility.

Vascular Endothelial Growth Factor A (VEGFA) pro-angiogenic isoforms stimulate while anti-angiogenic isoforms inhibit progression of follicles to later stages of development. Furthermore, inappropriate regulation of these isoforms may alter the primordial follicle pool. Therefore, we hypothesized that loss of all VEGFA isoforms in granulosa cells would affect ovarian reserve and follicular development. To test this hypothesis we evaluated...