Review paper
Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy
Abstract
Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes ( HLA-DRB1 / HLA-DQA1 )...
Paper Details
Title
Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy
Published Date
Mar 9, 2017
Journal
Volume
7
Issue
1
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