Original paper
Intravascular hemolysis and the pathophysiology of sickle cell disease
Abstract
Hemolysis is a fundamental feature of sickle cell anemia that contributes to its pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote vasomotor dysfunction, proliferative vasculopathy, and a multitude of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension, leg ulcers,...
Paper Details
Title
Intravascular hemolysis and the pathophysiology of sickle cell disease
Published Date
Mar 1, 2017
Volume
127
Issue
3
Pages
750 - 760
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Notes
History