Astrocytoma

Molecular biology

Biology

Psychiatry

Cancer research

Glioma

Genetics

Pediatrics

Vemurafenib

Metastatic melanoma

Epilepsy

Internal medicine

Girl

Medicine

Ganglioglioma

Cancer

Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) is arare primary neuroepithelial brain tumour, which typicallyoccurs in infants aged between 1 and 24 months. Knowledge ofthe genetic background of DIA/ DIG is very limited, recentlythe presence of BRAFV600E mutation was described in some casesof DIA/DIG. We present a case of 11-month old girl with 5-monthhistory of nystagmus.

Objective response to vemurafenib in a child treated formetastatic desmoplastic infantile