Sestrin2 protects against acetaminophen-induced liver injury
Abstract
Acetaminophen (APAP) overdose accounts for half of the cases of acute liver failure worldwide. We previously reported that Sestrin2 (Sesn2) protects against d-galactosamine/lipopolysaccharide-induced acute fulminant liver failure. In this study, we demonstrated that Sesn2 protects APAP-induced liver injury in mice, using a recombinant adenovirus encoding Sesn2 (Ad-Sesn2). First, we found that treatment of mice with toxic levels of APAP...
Paper Details
Title
Sestrin2 protects against acetaminophen-induced liver injury
Published Date
May 1, 2017
Volume
269
Pages
50 - 58
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