AHR toxicity and signaling: Role of TIPARP and ADP-ribosylation

The aryl hydrocarbon receptor is best known for its ability to mediate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, AHR plays important roles in the immune system, cell growth and numerous other cell functions. Similar to other transcription factors, tight control of AHR activity is necessary to prevent its over-activation. The AHR target gene, TCDD-inducible poly-ADP-ribose polymerase (TIPARP) was recently reported...