Original paper
Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis
Abstract
miR-146a, a strong pro-apoptotic factor in some pathophysiological processes, is reported to be involved in ischemic stroke (IS), though its role remains unclear. Fbxl10 is an active anti-apoptotic factor and a predicted target of miR-146a. We hypothesized that dysregulation of miR-146a contributes to ischemic injury by targeting Fbxl10.Circulating miRNAs were detected by miRNA microarray and qRT-PCR. miR-146a targets were predicted using...
Paper Details
Title
Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis
Published Date
Jul 1, 2017
Journal
Volume
107
Pages
156 - 167
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Notes
History