Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

Volume: 40, Issue: 2, Pages: 167 - 180
Published: Feb 3, 2017
Abstract
Histone deacetylase inhibitors (HDACi) are anti-neoplastic agents that are known to affect the growth of different cancer types, but their underlying mechanisms are still incompletely understood. Here, we compared the effects of two HDACi, i.e., Trichostatin A (TSA) and Valproic Acid (VPA), on the induction of cell death and autophagy in pancreatic cancer-derived cells that exhibit a high metastatic capacity and carry KRAS/p53 double mutations....
Paper Details
Title
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells
Published Date
Feb 3, 2017
Volume
40
Issue
2
Pages
167 - 180
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