Original paper
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
Abstract
Receptor tyrosine kinase (RTK) signaling is tightly regulated by protein allostery within the intracellular tyrosine kinase domains. Yet the molecular determinants of allosteric connectivity in tyrosine kinase domain are incompletely understood. By means of structural (X-ray and NMR) and functional characterization of pathogenic gain-of-function mutations affecting the FGF receptor (FGFR) tyrosine kinase domain, we elucidated a long-distance...
Paper Details
Title
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
Published Date
Feb 6, 2017
Journal
Volume
6
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Notes
History