Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes

Calcium (Ca2+) leak during cardiac diastole is chiefly mediated by intracellular Ca2+ channel/Ryanodine Receptors. Increased diastolic Ca2+ leak has been proposed as the mechanism underlying the appearance of hereditary arrhythmias. However, little is known about alterations in diastolic Ca2+ leak and the specific roles played by key intracellular Ca2+-handling proteins in hyperthyroidism, a known arrhythmogenic condition. We sought to determine...