Epigenetic Regulation of Noncoding RNA Transcription by Mammalian RNA Polymerase III

Published on Jan 23, 2017in Epigenomics4.112
· DOI :10.2217/EPI-2016-0108
Jong Lyul Park11
Estimated H-index: 11
(Korea Research Institute of Bioscience and Biotechnology),
Young-Jong Lee + 2 AuthorsYong Sun Lee19
Estimated H-index: 19
RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively ‘Pol III genes’) whose early established biological roles were so essential that they were considered ‘housekeeping genes’. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
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