Epigenomics
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Papers 1305
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#1Fabio Coppedè (UniPi: University of Pisa)H-Index: 37
Tweetable abstract The diagnostic application of genome-wide methylation signatures is increasing in various syndromic forms of autism, but further studies are warranted to clarify whether epigenetic biomarkers can be of diagnostic utility in idiopathic ASD.
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#1Vidya Chidambaran (Cincinnati Children's Hospital Medical Center)H-Index: 21
#2Tesfaye B. Mersha (Cincinnati Children's Hospital Medical Center)H-Index: 14
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#1Diana Montezuma (University of Porto)
#2Ana Teixeira-Marques (University of Porto)
Last. Rui Henrique (University of Porto)H-Index: 57
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Aims: The genetic association between Behcet's disease susceptibility and IL-10 has been confirmed in multiple cohorts, but the underlying mechanism of this association remains unclear. Materials & methods: We combined public resources and laboratory experiments (electrophoretic mobility shift assays, chromatin immunoprecipitation, luciferase reporter gene and CRISPR/Cas9 genome editing) to analyze transcription factor binding and enhancer activity controlling IL-10 expression. Results & conclus...
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#1Junhui Liang (SDU: Shandong University)
#2Wenjing Sun (SDU: Shandong University)
Last. Hui Zhang (SDU: Shandong University)H-Index: 7
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Aim: To investigate the role and function of NOL6, a protein related to ribosome biogenesis, in endometrial cancer. Methods: Methyl thiazolyl tetrazolium assay, colony formation assay, flow cytometry apoptosis assay, transwell assay and wound healing assays were carried out for evaluating cell proliferation, migration and apoptosis. Immunohistochemistry, western blot and tumor xenograft assays were carried out for detecting the level of protein expression and tumor formation. Results: We demonst...
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#1Vijayashree Priyadharsini Jayaseelan (Saveetha University)H-Index: 3
#2Paramasivam Arumugam (Saveetha University)H-Index: 2
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#1Diana L. Juvinao-Quintero (Harvard University)H-Index: 3
#2Andres Cardenas (University of California, Berkeley)H-Index: 19
Last. Marie-France Hivert (Harvard University)H-Index: 54
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Background: Previous studies suggest that fetal programming to hyperglycemia in pregnancy is due to modulation of DNA methylation (DNAm), but they have been limited in their maternal glycemic characterization. Methods: In the Gen3G study, we used a principal component analysis to integrate multiple glucose and insulin values measured during the second trimester oral glucose tolerance test. We investigated associations between principal components and cord blood DNAm levels in an epigenome-wide a...
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#1Rui Luo (U of M: University of Memphis)
#2Hongmei Zhang (U of M: University of Memphis)H-Index: 27
Last. Fawaz Mzayek (U of M: University of Memphis)H-Index: 22
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Background: To investigate the intergenerational effects of grandmaternal smoking during pregnancy (GMSDP) on the DNA methylation of grandchildren. Methods: Data from the Isle of Wight birth cohort with information regarding GMSDP and DNA methylation profiling at the birth of grandchildren (n = 161) were used. Differentially methylated CpG sites related to GMSDP were identified using testing-training screening, analysis of variance and multivariate analysis of covariance. The association between...
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#1Markos Tesfaye (NIH: National Institutes of Health)H-Index: 1
#2Suvo Chatterjee (NIH: National Institutes of Health)H-Index: 1
Last. Fasil Tekola-Ayele (NIH: National Institutes of Health)H-Index: 18
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Aim: To investigate the association between placental genome-wide methylation at birth and antenatal depression and stress during pregnancy. Methods: We examined the association between placental genome-wide DNA methylation (n = 301) and maternal depression and stress assessed at six gestation periods during pregnancy. Correlation between DNA methylation at the significantly associated CpGs and expression of nearby genes in the placenta was tested. Results: Depression and stress were associated ...
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#1Zhongjing Zhang (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
#2Percy David Papa Akuetteh (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
Last. Qiyu Zhang (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
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Aims: To develop a ferroptosis gene-based survival-predictor model for predicting the prognosis of patients with digestive tract tumors, a pan-caner analysis was performed. Materials & methods: Based on unsupervised clustering and the expression levels of ferroptosis genes, patients with cancer were divided into two clusters. The least absolute shrinkage and selection operator method Cox regression analysis was used to establish the survival-predictor model. Results: Based on the pan-cancer anal...
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Top fields of study
DNA methylation
Methylation
Epigenetics
Cancer research
Genetics
Biology