Evaluation of [ 18 F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer
Abstract
Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhibitors (ATRi) have already undergone clinical testing in cancer. For more accurate patient selection, monitoring and staging, real-time in vivo imaging of ATR could be invaluable; the development of...
Paper Details
Title
Evaluation of [ 18 F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer
Published Date
May 1, 2017
Journal
Volume
48
Pages
9 - 15
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